Tuesday, July 22, 2014

[Genetic, environmental, and epigenetic contribution to the susceptibility to autism spectrum disorders].

Rev Neurol. 2013 Dec 16;57(12):556-68.
[Genetic, environmental, and epigenetic contribution to the susceptibility to autism spectrum disorders].
[Article in Spanish]
Author information


Abstractin English, Spanish
INTRODUCTION:
Autism spectrum disorders (ASD) are common and complex neuropsychiatric disorders in which multiple factors may contribute to the phenotype.
AIM:
To review current knowledge about possible risk factors for ASD.
DEVELOPMENT:
Medline, OMIM and Ensembl databases were searched for possible risk factors, disease and gene information.
CONCLUSIONS:
There is genetic heterogeneity and probably different modes of transmission in ASD. In addition, many cases are related with non-inherited de novo mutations or uncommon alleles with a large effect. The general heritability in these disorders may be lower than previously reported. Some fraction of it may be explained by relatively common alleles that tend to have a small effect. To some extent, susceptibility alleles may have a different influence on the phenotype depending on other genetic or non-genetic factors. Non-genetic factors in the perinatal and postnatal period, including epigenetics, the age of the father and possibly the age of grandparents at conception may be relevant for ASD. The mechanisms involved in the etiology of ASD may be related with synaptic development and connectivity, neurotransmission, signaling, neuroplasticity, and gene expression. Different methods have contributed to understand the etiology of ASD. Linkage and association studies are not appropriate for ASD cases with de novo mutations with a strong effect. The observed increase in ASD prevalence may be related not only with more awareness, changing diagnostic criteria, and environmental exposures, but also with epigenetic changes, and an increasing number of de novo mutations.
PMID: 24288105 [PubMed - indexed for MEDLINE]


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Saturday, June 14, 2014

Strong male bias drives germline mutation in chimpanzees.

Science. 2014 Jun 13;344(6189):1272-1275. Epub 2014 Jun 12.
Strong male bias drives germline mutation in chimpanzees.
Author information


Abstract
Germline mutation determines rates of molecular evolution, genetic diversity, and fitness load. In humans, the average point mutation rate is 1.2 × 10-8 per base pair per generation, with every additional year of father's age contributing two mutations across the genome and males contributing three to four times as many mutations as females. To assess whether such patterns are shared with our closest living relatives, we sequenced the genomes of a nine-member pedigree of Western chimpanzees, Pan troglodytes verus. Our results indicate a mutation rate of 1.2 × 10-8 per base pair per generation, but a male contribution seven to eight times that of females and a paternal age effect of three mutations per year of father's age. Thus, mutation rates and patterns differ between closely related species.

Copyright © 2014, American Association for the Advancement of Science.

Thursday, May 22, 2014

Paternal age a determinant of birth success rates with stimulated IUI - Medical News Today

Paternal age a determinant of birth success rates with stimulated IUI - Medical News Today

Wednesday, May 21, 2014

Photographic Proof That Cavities Heal

Photographic Proof That Cavities HealPhotographic Proof That Cavities Heal






29


The compelling article written by Dr. Judene Smith DDS recently about how cavities heal really brought out the conventional dentists in droves! It has been awhile since I had to delete so many nasty, insulting, even threatening comments from a single blog post!
A sad testament indeed to how closed-minded and condescending a large portion of the dental community can be even toward one of its own.
The truth is that cavities can heal and the vehement denial by conventional dentists who react in a defensive manner (as if they have all the answers) does not change this fact one iota.
To drive another nail in the coffin of the notion that cavities must be filled and can’t remineralize and heal on their own, I am presenting a series of photographs sent to me by Rami Nagel, author of the paradigm shattering book Cure Tooth Decay.
The photos are of an 18 month old child from Baton Rouge, Louisiana.  Rikki, the boy’s mother, took these photos as her son’s cavities remineralized over a period of 8 weeks after commencing a dietary program which included supplementing with fermented cod liver oil and high vitamin butter oil.  It is important to note that regular cod liver oil will not produce the same spectacular results you see in these photos.
The sad truth is that when a parent brings in a child with significant tooth decay, toxic, IQ lowering fluoride treatments, drilling/filling or even crowns and root canals are recommended on baby teeth!  These treatments which can be incredibly expensive are not necessary as in a majority of cases, children’s teeth will quickly remineralize with dietary intervention. Adult teeth with cavities will heal in similar fashion as long as they have never been drilled or compromised by dental treatments in the past.
What Did This Child Eat That Caused These Cavities?
Possibly the most shocking thing about this story is that this toddler was not eating a junk food diet when these cavities formed.  He was still breastfeeding and eating an all-organic diet.  His favorite foods consisted of graham crackers and flaxseed bread.  He also was fond of organic granola bars which he ate regularly.
The problem with store bought whole grain products is that they are high in anti-nutrients like phytic acid that block mineral absorption. These foods are not a good choice for regular consumption by growing children.
Rikki’s son also ate fruits and vegetables and organic eggs although his mother avoided butter and milk thinking they were bad for him. After reading Cure Tooth Decay, she realized that butter and milk from grassfed cows are very healing and strengthening for teeth and bones. Grassfed dairy also counteracts some (but not all) of the negative effects of the toxins and anti-nutrients in processed grain products from the store.
Foods That Healed this Child’s Teeth
Rikki implemented 4 major changes to her son’s diet in order to achieve the results you see below.
  1. She cut out grains and sugars. This reduced the mineral depletion from the commercial grains and sugar.
  2. She started giving him Green Pasture’s Royal Blend (a combination product of blended fermented cod liver oil and butter oil) which gave her son the needed fat-soluble vitamins to remineralize his teeth.
  3. Her son now gets raw milk and raw milk cheese regularly along with fermented vegetables like pickles.
  4. Their family now uses butter liberally, and Rikki makes homemade broths and soups from pasture raised chicken.
Unfortunately, the earliest picture is of the teeth after 1 week on the new dietary protocol described in Cure Tooth Decay.  There wasn’t a control picture available of what the cavities looked like before any changes were made. Even still, the visual healing that takes place is compelling and should give every parent hope that cavity problems can be dealt with at home with simple dietary changes in the majority of cases.
Will these dietary interventions be easy? Most definitely not if a conventional diet is being followed. For those already eating a whole foods based diet in their home, the changes are much easier to accomplish. Far and away the most difficult change to implement for cavity prone children especially if they attend school is eliminating the processed grain based foods.
What do you think of these photos?  Do they finally put to bed the repeated denials from conventional dentists that cavities don’t heal and must be filled?
*These photographs were used with Mr. Nagel’s permission (source).







Additional Information

- See more at: http://www.thehealthyhomeeconomist.com/photographic-proof-cavities-heal/?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+TheHealthyHomeEconomist+%28The+Healthy+Home+Economist%29#sthash.uQsKlkt9.dpuf

Turns Out Coconut Oil Has A Major Dark Side

Turns Out Coconut Oil Has A Major Dark Side

Tuesday, May 20, 2014

Millions Fall Prey To This Deadly Breast Cancer Myth




Posted on: Tuesday, May 20th 2014 at 9:15 am
Written By: Sayer Ji, Founder

Millions of asymptomatic women undergo breast screening annually because their doctors tell them to do so. Not only are these women's presumably healthy breasts being exposed to highly carcinogenic x-rays, but thousands have received a diagnosis of 'breast cancer' for entirely benign lesions that when left untreated would have caused no harm to them whatsoever.
New Study: 80% of early-stage breast cancers do not progress to more concerning forms (invasive breast cancer) even after 20 years.
A new study published in the International Journal of Cancer titled, "Is carcinoma in situ a precursor lesion of invasive breast cancer?," is bringing much needed attention to a long standing cancer myth that is harming tens of thousands of women each year: that in situ (non- or slow-growing) breast lesions (carcinoma) inevitably progress to malignant cancers that will cause harm or death if left untreated through conventional methods.  This is simply not true. 
The 25-year prospective follow-up study measured the probability of development of invasive breast cancer (BC) following the diagnosis of carcinomas in situ (CIS) by linking the Canadian National Breast Screening Study (CNBSS) to cancer registries and a national vital statistics database. CIS was classified into ductal (DCIS) and lobular carcinoma in situ (LCIS).
The study found that while the average time from the diagnosis of CIS to invasive BC was 6.3 years (±5.6), and the 20-year cumulative incidence probabilities for DCIS and LCIS were 19.0% (95%CI: 11.2, 26.8) and 21.3% (95%CI: 7.1, 35.4) respectively, at 20-year post CIS diagnosis, more than 80% of them remained free of invasive BC.
Clearly, the notion that DCIS and LCIS always progress to invasive cancer, and therefore must be treated aggressively with the present-day 'standard of care' -- lumpectomy, mastectomy, radiation, and chemotherapy -- is disproved.  In other words, the natural history of in situ lesions like DCIS – commonly misidentified by conventional oncologists as 'cancers' – indicate they progress to invasive breast cancer only 20% of the time, even after 20 years without treatment. 
The study concluded:
"This low probability of developing invasive BC post CIS diagnosis does not support the notion that CIS of the breast is an obligate precursor lesion of invasive BC."
Even 'Invasive Breast Cancer' Is Misunderstood
The misunderstanding about in situ breast lesions extends to so-called 'invasive breast cancer' (BC) as well. Whereas invasive BC is considered by the conventional medical establishment as a lethal disease process that must be cut, burned or poisoned out of the body as soon as it is found, there is great heterogeneity within this biological category, including forms with very low (indolent) and high risk for progression and death, and the whole gamut types between.  Also, several years ago, the journal Lancet Oncology found that some clinically verified "invasive" cancers appear to regress with time if left untreated, further complicating matters:
"Because the cumulative incidence among controls did not reach that of the screened group, we believe that many invasive breast cancers detected by repeated mammography screening do not persist to be detected by screening at the end of 6 years, suggesting that the natural course of many of the screen-detected invasive breast cancers is to spontaneously regress." [emphasis added]
The present inability of the conventional medical system to identify any clear method to determine the difference between a benign, malignant, or possibly regression-prone form of BC, puts the patient at profound risk of overdiagnosis and overtreatment, the consequences of which can be devastating. The lack of individualized treatment and informed choice leads many women to undergo treatment who may have never experienced disease progression had they chosen to employ watchful waiting, or alternative approaches.
The Larger Issue: 'Cancer' Has Been Completely Misunderstood To The Detriment of Millions
A 2013 study published in JAMA titled, "Overdiagnosis and Overtreatment in Cancer: An Opportunity for Improvement,"[1] explains that the word cancer is highly misunderstood and misused.  It has become clear that after 30 years of cancer screening with an emphasis on 'detecting cancer early,' the goals of such campaigns to reduce the rate of late-stage disease and decrease cancer mortality has clearly not been realized. [See video for an in-depth explanation.] This would not happen if the exponential increase of diagnoses and treatment for 'early stage' cancer produced as a result of mammography screening over the past 25 years were actually finding 'cancers,' and not so-called indolent lesions of epithelial origin – i.e. benign lesions that will not progress to malignancy. 
The new study expanded on these implications:
"What has emerged has been an appreciation of the complexity of the pathologic condition called cancer. The word "cancer" often invokes the specter of an inexorably lethal process; however, cancers are heterogeneous and can follow multiple paths, not all of which progress to metastases and death, and include indolent disease that causes no harm during the patient's lifetime. Better biology alone can explain better outcomes."
"Use of the term "cancer" should be reserved for describing lesions with a reasonable likelihood of lethal progression if left untreated. There are 2 opportunities for change. First, premalignant conditions (e.g., ductal carcinoma in situ or high-grade prostatic intraepithelial neoplasia) should not be labeled as cancers or neoplasia, nor should the word "cancer" be in the name. Second, molecular diagnostic tools that identify indolent or low-risk lesions need to be adopted and validated. Another step is to reclassify such cancers as IDLE (indolent lesions of epithelial origin) conditions."

Fundamentally, overdiagnosis results from the fact that screen-detected 'cancers' are 
disproportionately slower growing ones, present with few to no symptoms, and would never progress to cause harm if left undiagnosed and untreated.  The figure below depicts four arrows representing four types of abnormal cell growth: 1) Fast 2) Slow 3) Very Slow 4) Non-Progressive. 

Unless the abnormal cell growth reaches a size at which cancer symptoms occur, it is not justifiable to treat it; nor is it appropriate to call it 'cancer,' as technically it is an indolent or benign lesion. Faster growing cells can contribute to symptoms over a life time, but even then, that does not mean that it will necessarily progress to cause death before natural or other causes take the patients life. In fact, premature treatment can greatly reduce the quality and length of life due to the side effects of chemotherapy, radiation, surgery, and the added stress and psychospiritual trauma of receiving a diagnosis.
The Implications of This Cancer Reclassification To the Healthy and  'Cancer Survivors'
There are two primary implications of this reclassification of 'cancer.' First, those undergoing 'preventive' cancer screening need to be aware of how frequently overdiagnosis occurs (up to 50% within 10 years), especially in breast, lung, prostate and thyroid 'cancers'-- the most prevalent lesions overdiagnosed through routine screening, and indiscriminately treated regardless of differing risk stratifications.  For instance, before the advent of mammography, only 3% of detected breast cancer were identified as DCIS.[2] Today, more than one-third of screen-detected early cancers are DCIS, with the unfortunate result that 33% of those diagnosed with DCIS receiving breast removal (mastectomy), 48% receiving lumpectomy and radiation treatments, 16% receiving lumpectomy, and only 3% electing to do nothing.[3]  The fact that DCIS will do no harm in at least 80% of the time reveals a great burden of iatrogenic harm is being borne by women who are being coerced by an outdated treatment model that is no longer sufficiently evidence-based.
Second, there are now millions of formerly screened, and subsequently treated, patients who had indolent lesions of epithelial origin, such as DCIS, LCIS, or in the case of men, high grade intraepithelial hyperplasia (HGIH) ('prostate cancer'), whose diagnoses were invalid and should never have been treated. For instance, it has been estimated that 1.3 million women were falsely diagnosed with and treated for 'breast cancer' in the past 30 years.  These patients believe they are 'cancer' survivors, when in fact they are surviving the psychospiritual and physical traumas and abuses of their treatments and not their 'disease.' While not knowing the truth may be considered somewhat protective against further trauma associated with no longer identifying with the aggressor – i.e. the conventional medical model – and the potentially devastating realization that they have succumbed to disfigurement and poisoning from unnecessary treatments, along with co-option by cause marketing campaigns – Breast Cancer Awareness Month; Pink Ribbons; Race for the Cure -- encouraging them to act as brand ambassadors for breast cancer associated products and services, and drawing other otherwise healthy women into receiving unnecessary and/or dangerous diagnoses and treatments generated by screening programs. This process I have described in the context of the breast cancer industry 'memeplex,' which I presented on in Washington in 2013 at the Mind-Body Week Conference. You can watch part of my lecture here.
Moving the Paradigm Forward
Over the past few years, a number of studies have been published revealing a paradigm shift in our understanding of cancer. Some of these findings reveal:
For additional research on natural/integrative cancer treatments and the unintended, adverse effects of conventional ones, view the following health guides on Greenmedinfo.com:



[2] Laura Esserman, MD, MBA; and Michael Alvarado, MD  Setting a Research Agenda for Ductal Carcinoma In Situ That Meets the Current Need for Change Ann Intern Med. 2014;160(7):511-512. doi:10.7326/M14-0435


[3] IBID

6 Metabolism Death Foods

by Dr. Josh Axe



There is nothing worse than starting an exercise program, making some good diet changes, but still not seeing the results you want to see.  Has that ever been you?  It can be really frustrating.
The reason this happens is, even though you think you’re consuming a healthy diet, there is often some hidden food in your diet that is ruining your weight loss efforts.
The foods that keep you from losing the last 10 pounds and keep you stuck at a plateau are what I call the metabolism death foods!
The term may sound scary, and it can be.  Your body recognizes these foods as toxins and puts your body into a fight or flight response.
These foods alter the focus of your metabolism and can cause:
  • Weight gain
  • Thyroid dysfunction
  • Fatigue
  • Hormone imbalance
  • Digestive disease
And the craziest thing about these foods is that they are often labeled as “health foods”.
Here are the 6 metabolism death foods you need to switch out of your diet to take your metabolism and fat burning potential to the next level!
6 Metabolism Death Foods

1. Fruit Juice – Contrary to popular belief, fat isn’t the first thing that will make you fat, it’s consuming too much sugar.  Drinking fruit juice and consuming too much sugar will absolutely wreck your metabolism!
Fruit juice including most apple, orange and grape juice is basically chemically laden sugar water! I know something like apple juice sounds healthy, but the process of turning an apple into juice is as follows.
First, they press the apple and remove all of the fiber, then they heat it up through pasteurization at 280 degrees, then it’s dried and turned into a concentrate, then finally, they add in sugar, food coloring and flavorings and that is the apple juice you buy today.
One 8 ounce glass of fruit juice contains 30 grams of sugar where a soda contains 28 grams of sugar!
Also, you should avoid other forms of sugar which can hide under names like: corn syrup, dextrose, fructose, juice concentrate, maltodextrin, raw sugar and brown sugar.
What to do instead:  To replace fruit juice I recommend making homemade lemonade mixing real lemon juice, water and stevia.  Kombucha is another great option as well as herbal tea mixed with raw honey.  Or, drinking coconut water which is nature’s gatorade is another great option!

2. Whole Grains – Whole grains may be the #1 offender when it comes to ruining your metabolism and weight loss efforts.  I know it may seem like “whole grains” like wheat bread are healthy but most are far from helping your metabolism.
Three of the main compounds in grains hurt your metabolism include gluten, starch and phytic acid.  Gluten causes inflammation, starch turns into sugar quickly and phytic acid binds to minerals so you’re not getting most of the minerals and vitamins from whole grains that could have helped your metabolism.
Some of the biggest whole grain offenders include: bread, pasta, cereal, crackers, muffins, desserts, flours, chips and granola bars.
What to do instead: A better option for fat loss is replacing your daily intake of grains with fruits and vegetables or consuming up to 1 piece daily of a sprouted grain bread or sourdough.  Also, the best flour replacement to use instead of wheat flour is coconut flour.  Coconut flour is a dieters best friend because it’s high in fiber which supports rapid fat loss and contains fats your body can burn as fuel.

3. Canola Oil – Using the wrong type of oil can keep you from losing that last 10 pounds and put a halt to any results you might see.  If you use canola oil or other vegetable oils it’s sure to slow down your fat loss efforts and cause you to store unwanted body fat.  Canola oil contains hydrogenated oils which cause inflammation throughout the entire body disrupting your hormones and metabolism.
Also, 90% of canola oil is genetically modified (GMO), which means they are hard wired with pesticides that cause cellular toxicity which destroys your bodies metabolism and overall health.
What to do instead: Replace all vegetables oils with coconut oil and grass-fed butter to boost your metabolism.  I always say, butter is your belly’s best friend.  Grass-fed butter supports metabolism because it is high in CLA and coconut oil supports fat loss because it’s high in MCFA’s.  Consuming these two sources of fat will turn your body into a fat burning furnace!

4. Peanut Butter – Yes, peanut butter is tasty, but it can also kill your gut health.  Peanuts are grown on the soil and stored moist in silos which then cause them to grow a type of fungus called aflatoxins which can effect the health of your gut.
Peanuts are one of the most common allergens today and have been linked to food sensitivities, leaky gut and a slow metabolism.  This aflatoxin in peanuts can compete with probiotics in your gut which we know damages digestive health.
Also, peanuts are very high in omega-6 fatty acids which can cause serious inflammation in the body.  For these many reasons, peanut butter is a metabolism death food!
What to do instead: If you want to start revving up your metabolism then make a switch to almond butter.  Almonds are high in an amino acid L-arginine which increases HGH production in your body.  This is turn causes your body to build lean muscle which sends your metabolism sky high!
Just 1 tbsp spoon of almond butter with celery, in a smoothie or with some apples are great snacks to re-ignite your metabolism.

5. Granola - This “health food” has had a health halo around it for years but it’s secretly been hiding as a wolf in sheep’s clothing that kills your metabolism.
Today’s granola has many issues in that it’s made up of whole grains and sugar.  Now what’s most surprising about granola is that the honey in it is a major cause of weight gain.  A study at Texas A&M University tested honey and found 76% of it contained no pollen whatsoever and it had been high temperature pasteurized so it is no better than corn syrup!
The combination of gluten, phytic acid and processed honey is what makes this treat lethal to your metabolism and diet goals.
What to do instead: A great replacement to store bough granola is to make homemade sprouted granola.  Simply soak almonds, pecans, cashews and chia seeds in water for 8 hours then set them out for a day on a paper towel.  Then mix these ingredients with raw local honey, raisins, coconut flakes, cinnamon and sea salt.  Place them in a dehydrator or oven and you have a great tasting metabolism boosting snack.

6. Artificial Sweeteners – Of all the metabolism death foods, artificial sweeteners including aspartame and sucralose are probably the most deceiving.
Artificial sweeteners tell the lie that you can satisfy your sweet tooth, with no calories, no guilt and a thinner waist line.  However, aspartame is actually linked to 92 adverse health effects.
Aspartame and sucralose (Splenda) can stimulate your appetite and increase cravings for carbohydrates. The calorie “savings” from consuming foods sweetened with aspartame ends up not saving you anything due to the increase in appetite and therefore calorie consumption.
The MESA study evaluated the effect of diet soda consumption on rates of obesity, metabolic syndrome, and diabetes in over 6,000 participants. It was found that the consumption of just one diet soda per day significantly increased the risk for increased waist circumference and weight gain.

What to do instead: Switch out artificial sweeteners for stevia an all natural no calorie sweetener.  Also, raw honey and dates are other great options.

Millions Fall Prey To This Deadly Breast Cancer Myth


Posted on: Tuesday, May 20th 2014 at 9:15 am
Written By: Sayer Ji, Founder

Millions of asymptomatic women undergo breast screening annually because their doctors tell them to do so. Not only are these women's presumably healthy breasts being exposed to highly carcinogenic x-rays, but thousands have received a diagnosis of 'breast cancer' for entirely benign lesions that when left untreated would have caused no harm to them whatsoever.
New Study: 80% of early-stage breast cancers do not progress to more concerning forms (invasive breast cancer) even after 20 years.
A new study published in the International Journal of Cancer titled, "Is carcinoma in situ a precursor lesion of invasive breast cancer?," is bringing much needed attention to a long standing cancer myth that is harming tens of thousands of women each year: that in situ (non- or slow-growing) breast lesions (carcinoma) inevitably progress to malignant cancers that will cause harm or death if left untreated through conventional methods.  This is simply not true. 
The 25-year prospective follow-up study measured the probability of development of invasive breast cancer (BC) following the diagnosis of carcinomas in situ (CIS) by linking the Canadian National Breast Screening Study (CNBSS) to cancer registries and a national vital statistics database. CIS was classified into ductal (DCIS) and lobular carcinoma in situ (LCIS).
The study found that while the average time from the diagnosis of CIS to invasive BC was 6.3 years (±5.6), and the 20-year cumulative incidence probabilities for DCIS and LCIS were 19.0% (95%CI: 11.2, 26.8) and 21.3% (95%CI: 7.1, 35.4) respectively, at 20-year post CIS diagnosis, more than 80% of them remained free of invasive BC.
Clearly, the notion that DCIS and LCIS always progress to invasive cancer, and therefore must be treated aggressively with the present-day 'standard of care' -- lumpectomy, mastectomy, radiation, and chemotherapy -- is disproved.  In other words, the natural history of in situ lesions like DCIS – commonly misidentified by conventional oncologists as 'cancers' – indicate they progress to invasive breast cancer only 20% of the time, even after 20 years without treatment. 
The study concluded:
"This low probability of developing invasive BC post CIS diagnosis does not support the notion that CIS of the breast is an obligate precursor lesion of invasive BC."
Even 'Invasive Breast Cancer' Is Misunderstood
The misunderstanding about in situ breast lesions extends to so-called 'invasive breast cancer' (BC) as well. Whereas invasive BC is considered by the conventional medical establishment as a lethal disease process that must be cut, burned or poisoned out of the body as soon as it is found, there is great heterogeneity within this biological category, including forms with very low (indolent) and high risk for progression and death, and the whole gamut types between.  Also, several years ago, the journal Lancet Oncology found that some clinically verified "invasive" cancers appear to regress with time if left untreated, further complicating matters:
"Because the cumulative incidence among controls did not reach that of the screened group, we believe that many invasive breast cancers detected by repeated mammography screening do not persist to be detected by screening at the end of 6 years, suggesting that the natural course of many of the screen-detected invasive breast cancers is to spontaneously regress." [emphasis added]
The present inability of the conventional medical system to identify any clear method to determine the difference between a benign, malignant, or possibly regression-prone form of BC, puts the patient at profound risk of overdiagnosis and overtreatment, the consequences of which can be devastating. The lack of individualized treatment and informed choice leads many women to undergo treatment who may have never experienced disease progression had they chosen to employ watchful waiting, or alternative approaches.
The Larger Issue: 'Cancer' Has Been Completely Misunderstood To The Detriment of Millions
A 2013 study published in JAMA titled, "Overdiagnosis and Overtreatment in Cancer: An Opportunity for Improvement,"[1] explains that the word cancer is highly misunderstood and misused.  It has become clear that after 30 years of cancer screening with an emphasis on 'detecting cancer early,' the goals of such campaigns to reduce the rate of late-stage disease and decrease cancer mortality has clearly not been realized. [See video for an in-depth explanation.] This would not happen if the exponential increase of diagnoses and treatment for 'early stage' cancer produced as a result of mammography screening over the past 25 years were actually finding 'cancers,' and not so-called indolent lesions of epithelial origin – i.e. benign lesions that will not progress to malignancy. 
The new study expanded on these implications:
"What has emerged has been an appreciation of the complexity of the pathologic condition called cancer. The word "cancer" often invokes the specter of an inexorably lethal process; however, cancers are heterogeneous and can follow multiple paths, not all of which progress to metastases and death, and include indolent disease that causes no harm during the patient's lifetime. Better biology alone can explain better outcomes."

"Use of the term "cancer" should be reserved for describing lesions with a reasonable likelihood of lethal progression if left untreated. There are 2 opportunities for change. First, premalignant conditions (e.g., ductal carcinoma in situ or high-grade prostatic intraepithelial neoplasia) should not be labeled as cancers or neoplasia, nor should the word "cancer" be in the name. Second, molecular diagnostic tools that identify indolent or low-risk lesions need to be adopted and validated. Another step is to reclassify such cancers as IDLE (indolent lesions of epithelial origin) conditions."

older-paternal-age-reduces-iui-live-birth-rates/article/347487/

http://www.renalandurologynews.com/older-paternal-age-reduces-iui-live-birth-rates/article/347487/

Tuesday, May 06, 2014

April 2014, Vol 71, No. 4 > < Previous Article Full content is available to subscribers Subscribe/Learn More Next Article > Original Investigation | April 2014 Paternal Age at Childbearing and Offspring Psychiatric and Academic Morbidity Brian M. D’Onofrio, PhD1; Martin E. Rickert, PhD1; Emma Frans, MSc2; Ralf Kuja-Halkola, MSc2; Catarina Almqvist, MD2,3; Arvid Sjölander, PhD2; Henrik Larsson, PhD2; Paul Lichtenstein, PhD2 [+] Author Affiliations JAMA Psychiatry. 2014;71(4):432-438. doi:10.1001/jamapsychiatry.2013.4525. Text Size: A A A Article Figures Tables References Comments (2) ABSTRACT ABSTRACT | METHODS | RESULTS | DISCUSSION | CONCLUSIONS | ARTICLE INFORMATION | REFERENCES Importance Advancing paternal age is associated with increased genetic mutations during spermatogenesis, which research suggests may cause psychiatric morbidity in the offspring. The effects of advancing paternal age at childbearing on offspring morbidity remain unclear, however, because of inconsistent epidemiologic findings and the inability of previous studies to rigorously rule out confounding factors. Objective To examine the associations between advancing paternal age at childbearing and numerous indexes of offspring morbidity. Design, Setting, and Participants We performed a population-based cohort study of all individuals born in Sweden in 1973-2001 (N = 2 615 081), with subsets of the data used to predict childhood or adolescent morbidity. We estimated the risk of psychiatric and academic morbidity associated with advancing paternal age using several quasi-experimental designs, including the comparison of differentially exposed siblings, cousins, and first-born cousins. Exposure Paternal age at childbearing. Main Outcomes and Measures Psychiatric (autism, attention-deficit/hyperactivity disorder, psychosis, bipolar disorder, suicide attempt, and substance use problem) and academic (failing grades and low educational attainment) morbidity. Results In the study population, advancing paternal age was associated with increased risk of some psychiatric disorders (eg, autism, psychosis, and bipolar disorders) but decreased risk of the other indexes of morbidity. In contrast, the sibling-comparison analyses indicated that advancing paternal age had a dose-response relationship with every index of morbidity, with the magnitude of the associations being as large or larger than the estimates in the entire population. Compared with offspring born to fathers 20 to 24 years old, offspring of fathers 45 years and older were at heightened risk of autism (hazard ratio [HR] = 3.45; 95% CI, 1.62-7.33), attention-deficit/hyperactivity disorder (HR = 13.13; 95% CI, 6.85-25.16), psychosis (HR = 2.07; 95% CI, 1.35-3.20), bipolar disorder (HR = 24.70; 95% CI, 12.12-50.31), suicide attempts (HR = 2.72; 95% CI, 2.08-3.56), substance use problems (HR = 2.44; 95% CI, 1.98-2.99), failing a grade (odds ratio [OR] = 1.59; 95% CI, 1.37-1.85), and low educational attainment (OR = 1.70; 95% CI, 1.50-1.93) in within-sibling comparisons. Additional analyses using several quasi-experimental designs obtained commensurate results, further strengthening the internal and external validity of the findings. Conclusions and Relevance Advancing paternal age is associated with increased risk of psychiatric and academic morbidity, with the magnitude of the risks being as large or larger than previous estimates. These findings are consistent with the hypothesis that new genetic mutations that occur during spermatogenesis are causally related to offspring morbidity.



Original Investigation | April 2014

Paternal Age at Childbearing and Offspring Psychiatric and Academic Morbidity
Brian M. D’Onofrio, PhD1; Martin E. Rickert, PhD1; Emma Frans, MSc2; Ralf Kuja-Halkola, MSc2; Catarina Almqvist, MD2,3; Arvid Sjölander, PhD2; Henrik Larsson, PhD2; Paul Lichtenstein, PhD2
[+] Author Affiliations
JAMA Psychiatry. 2014;71(4):432-438. doi:10.1001/jamapsychiatry.2013.4525.
Text Size: A A A

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Abstract
ABSTRACT | METHODS | RESULTS | DISCUSSION | CONCLUSIONS | ARTICLE INFORMATION | REFERENCES

Importance  Advancing paternal age is associated with increased genetic mutations during spermatogenesis, which research suggests may cause psychiatric morbidity in the offspring. The effects of advancing paternal age at childbearing on offspring morbidity remain unclear, however, because of inconsistent epidemiologic findings and the inability of previous studies to rigorously rule out confounding factors.
Objective  To examine the associations between advancing paternal age at childbearing and numerous indexes of offspring morbidity.
Design, Setting, and Participants  We performed a population-based cohort study of all individuals born in Sweden in 1973-2001 (N = 2 615 081), with subsets of the data used to predict childhood or adolescent morbidity. We estimated the risk of psychiatric and academic morbidity associated with advancing paternal age using several quasi-experimental designs, including the comparison of differentially exposed siblings, cousins, and first-born cousins.
Exposure  Paternal age at childbearing.
Main Outcomes and Measures  Psychiatric (autism, attention-deficit/hyperactivity disorder, psychosis, bipolar disorder, suicide attempt, and substance use problem) and academic (failing grades and low educational attainment) morbidity.
Results  In the study population, advancing paternal age was associated with increased risk of some psychiatric disorders (eg, autism, psychosis, and bipolar disorders) but decreased risk of the other indexes of morbidity. In contrast, the sibling-comparison analyses indicated that advancing paternal age had a dose-response relationship with every index of morbidity, with the magnitude of the associations being as large or larger than the estimates in the entire population. Compared with offspring born to fathers 20 to 24 years old, offspring of fathers 45 years and older were at heightened risk of autism (hazard ratio [HR] = 3.45; 95% CI, 1.62-7.33), attention-deficit/hyperactivity disorder (HR = 13.13; 95% CI, 6.85-25.16), psychosis (HR = 2.07; 95% CI, 1.35-3.20), bipolar disorder (HR = 24.70; 95% CI, 12.12-50.31), suicide attempts (HR = 2.72; 95% CI, 2.08-3.56), substance use problems (HR = 2.44; 95% CI, 1.98-2.99), failing a grade (odds ratio [OR] = 1.59; 95% CI, 1.37-1.85), and low educational attainment (OR = 1.70; 95% CI, 1.50-1.93) in within-sibling comparisons. Additional analyses using several quasi-experimental designs obtained commensurate results, further strengthening the internal and external validity of the findings.

Conclusions and Relevance  Advancing paternal age is associated with increased risk of psychiatric and academic morbidity, with the magnitude of the risks being as large or larger than previous estimates. These findings are consistent with the hypothesis that new genetic mutations that occur during spermatogenesis are causally related to offspring morbidity.

Friday, May 02, 2014

5 Natural Antibiotic Solutions for Antibiotic-Resistant Infections

5 Natural Antibiotic Solutions for Antibiotic-Resistant Infections5 Natural Antibiotic Solutions for Antibiotic-Resistant Infections

March 25th, 2013
Updated 05/08/2013 at 2:30 pm
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Our dependence on antibiotics has helped us to create some monsters—these monsters are antibiotic-resistant infections like superbugs being transmitted in hospitals, certain strains of E coli., and MRSA. The infections, if you went the traditional route, would be hard (if not impossible) to kill. But, there are foods that act as natural antibiotics that may prove effective where modern medicine is failing.
As a whole, doctors have been prescribing antibiotics at the slightest sign of illness, even for things they simply won’t help like the common cold. These prescriptions have been routinely handed out like candy despite the fact that illness, including common infections, can be successfully treated with a healthy immune system and a few natural helpers. All of this over-prescribing has led the bacteria which causes these illnesses to morph, evolving in the interest of self-preservation, into strains that will not be stopped with antibiotics, even those antibiotics largely considered to be the last resort.
It might be time to try some natural alternatives – and stick with them.

5 Natural Antibiotics
You need foods, natural foods that will help foster a healthy immune system while annihilating bacterial invaders. Fortunately, there are several solutions that may just be in your kitchen right now.
  • Garlic - Garlic has known antibacterial, antifungal, and even antiviral properties. It has successfully be used to treat infectious diseases like pneumonia, MRSA, and even the black plague. It can also kill intestinal parasites—which can wreak havoc on your immune system.
  • Echinacea - People usually reach for the Echinacea tea to ward off a cold or the flu, but this powerful herb is a known infection-buster as well. The herb fights infections by strengthening the body’s own defense system, helping you to fight the bacteria rather than just coming in and killing everything in sight (like Big Pharma’s antibiotics).
  • Honey – Also among the many amazing natural antibiotics, honey is a well known food harnessing antibacterial properties (along with a bunch of other beneficial properties). One study published in the journal Microbiology found that honey – particularly that derived from bees foraging on manuka flowers – halted one type of streptococcus pyogenes from inhibiting the healing of wounds. Other research shows that honey could be a potent answer to drug resistant bacteria like MRSA. Honey is a great natural antibiotic.
  • Turmeric - The bright yellow spice that gives curries their rich color and smoky flavor, turmeric is far more than a culinary tool—it has amazing healing properties. MRSA typically forms in wounds or boils. Turmeric acts as an antibacterial agent and can be taken internally or applied directly to the skin. Try making turmeric into a paste by adding water or even manduka honey and applying to the infection.
  • Oregano -Oregano, and specifically oil of oregano, has potent antibacterial and infection-fighting properties. One study in particular found these properties to be as effective as antibiotics and offering great promise particularly in the fight against antibiotic-resistant infection. You can find this oil in health food stores or you can make your own.
The body is a miraculous machine and when properly maintained, it will fight off infections without assistance. Even when an extra boost is needed, we needn’t run to the doctor for a prescription. Instead, rely on natural antibiotics and healers to help maintain optimal health.
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Deadly MERS Outbreak Still ‘Incurable,’ Hits 30% Death Rate


April 29th, 2014
Updated 05/01/2014 at 12:27 pm
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About two years ago, around September of 2012, a highly resistant disease known as Middle East Respiratory Syndrome (MERS) was discovered in Saudi Arabia. While the disease has been floating around mostly in Saudi Arabia since then, the disease has recently made headlines, with hundreds of outbreaks occurring. The worst part? Not a single treatment is known.
MERS has infected hundreds of individuals so far. There are currently at least 339 cases reported in Saudi Arabia, with a whopping 102 deaths – that’s about a 30% death rate. What’s more, Saudi Arabia confirmed 26 more cases of Middle East Respiratory Syndrome just 2 days ago. But that isn’t the only affected country; 13 other nations are suffering from MERS infections, including:
  • Egypt
  • Jordan
  • Kuwait
  • Qatar
  • United Arab Emirates
  • Tunisia
  • Malaysia
  • Oman
  • France
  • Greece
  • Italy
  • United Kingdom
  • Philippines
The virus is characterized by fever, cough, diarrhea, shortness of breath, and can lead to pneumonia and kidney failure. It can almost seem like the flu. As the CDC reports, most people who became infected with MERS-CoV developed severe acute respiratory illness with symptoms of fever, cough, and shortness of breath. About half of them died.

No Known ‘Cure’
The seemingly worst part concerning this MERS outbreak is the fact that there is no known treatment. There is no Eastern nor Western medicine, including antibiotics, vaccines, or any other conventional treatment that can aid in this near-pandemic. In fact, the reliance on Western medicine may very well result in an even stronger strain of the virus – one which will prevail for an untold amount of time.
Even the CDC admits that the use of antibiotics have led to unstoppable, super bacteria. A recent report even goes so far as to admit that modern medicine has failed when it comes to managing infectious disease since Mother Nature always adapts to overcome isolated chemical weaponry concocted in some lab. Ever-newer strains of bacteria are developed to out-whit us. The age of antibiotics is coming to an end.

This is even more concerning when you consider that the MERS virus is highly infectious. The virus can spread among the population without requiring direct contact. In other words, it can be transferred through the air – an airborne infection.
“CDC recognizes the potential for the virus to spread further and cause more cases and clusters globally, including in the United States,” the agency said.
Indeed, MERS seems to embody all the characteristics of an extremely dangerous disease:
  • It is extremely contagious
  • It’s resistant/immune to known medical treatments
  • Symptoms fuel the spreading of the disease since it can be spread through a cough or sneeze
  • It has a long duration, asymptomatic incubation period
  • The death rate is high, but low enough to retain enough carries to continue the spread
While scientists have recently found natural human antibodies to the newly-emerging MERS virus which marks a step towards developing treatments, everyone must be careful to not expose themselves to this currently untreatable disease. In the mean time, familiarize yourself with every known healing and preventative tool, not just for this outbreak, but for all future outbreaks. Though Western medicine has it’s place, there is also great value in Eastern medicines herbal, nutritional, and alternative therapies.

Here are 5 natural antibiotic solutions to get you started.



Sugar The Bitter Truth

Sugar the Bitter Truth

http://www.uctv.tv/shows/Sugar-The-Bitter-Truth-16717Sugar the Bitter Truth

Pineal Gland Function

Pineal Gland FunctionPineal Gland Function
Posted on 2013/09/6




by Anna Hunt,
The pineal gland, an endocrine gland located in the brain, is said to be the seat of the soul. Also referred to as the Third Eye, this small gland is believed to be involved in reaching higher levels of consciousness, acting as a gateway to dimensions beyond our brain-created reality. To learn more about the pineal gland, see: What is the Pineal Gland?
For the people that seek to fully activate their spiritual potential and tap into the power of the pineal gland, one must begin by strengthening its function though detoxification and proper nutrition. Researchers are finding that in many people, due to our poor diet with pesticide and chemical-laden foods and environmental toxins such as fluoride in our water, the pineal gland and our entire bodies are becoming exposed to many more toxins and nano-organisms than ever before. These form calcium shells around themselves for protection from our immune systems which has resulted in calcification of the pineal gland, a build-up of calcium phosphate crystals in various parts of the human body. Many of us have a pineal gland that is already completely calcified. This does not fare well when we try to tap into the esoteric capabilities of this gland through yoga practice, meditation, using plant medicines such as ayahuasca, and so forth. The process of detoxification is an essential place to start if we want to exploit our full spiritual capabilities.
Below is a list, in no particular order, of 8 supplements that will boost your pineal gland function, help in its decalcification, and support you on your journey of personal and spiritual cultivation. Some of the supplements offer similar results, so it is up to you to decide which combination of supplements will work best for you.
1. Melatonin
The pineal gland already produces the hormone melatonin, which affects the body’s circadian rhythms of waking and sleeping. Melatonin is also associated with relaxation and visualization, and people often take melatonin supplements as a sleep aid or to help overcome jet-lag due to travel. When purchasing melatonin supplements, make sure the products are plant-based and not animal tested. It is suggested that you always start with the smallest dosage possible and do not use any melatonin supplement for longer than three months.
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2. Oregano Oil and Neem Extract
Both oregano oil and neem extract help in the purification process, helping to remove existing calcification within the pineal gland, in addition to purifying the body’s systems, especially the endocrine system. Neem has been used in this way in India for thousands of years. In the western world, oregano oil is also becoming a holistic way of fortifying the immune support system. In the longer term, both of these supplements will act as a natural antibiotic against new calcium shells created by nanobacteria.
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3. Raw Cacao
Raw, organic chocolate in its purest form can help detoxify the pineal gland because of cacao’s high antioxidant content. Cacao will also help stimulate the third eye.
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4. Chlorophyll-rich Superfoods
Supplements like spirulina, chlorella, wheatgrass and blue-green algae are examples of chlorophyll-rich superfoods that offer similar benefits to eating leafy greens but with much more nutrition packed into a small serving. These supplements assist in the decalcification of the pineal gland due to their strong detoxification properties.
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5. Raw Apple Cider Vinegar
A natural detoxifier, raw apple cider vinegar helps decalcify the pineal gland due to its malic acid properties. Malic acid is an organic compound that gives fruits their sour taste. When taken as a supplement, it supports the digestive system and helps the body detoxify. Apple cider vinegar has many health benefits, many of which are listed here. Ensure that the brand you buy is raw and packaged in a glass container.
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6. Iodine
Many of us have been exposed to sodium fluoride due to fluoridation of our water systems, and this has also resulted in the calcification of the pineal gland. Iodine, naturally occurring in plants such as seaweed, effectively improves the removal of sodium fluoride via urine. Unfortunately, the Western diet has left us deficient of this vital mineral while our bodies need it most. To avoid calcium deficiency when taking iodine supplements, a diet incorporating many organic foods such as kale, broccoli, almonds, oranges, flax seed, sesame seeds, dill, thyme and other dried herbs is recommended. It is suggested that a non-GMO lecithin supplement is also taken to compliment iodine intake.
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7. Organic Blue Ice Skate Fish Oil and Activator X (Vitamin K1/K2)
If you’d like to take a natural supplement to decalcify your pineal gland, organic blue ice skate fish oil may be one of the most powerful options out there. This oil contains Activator X – a detoxifier discovered by Weston Price that combines Vitamins K1 and K2 – which allows for the body to remove calcium from various locations throughout the body, such as the pineal gland and the arteries. Instead of eliminating the excess calcium, as iodine does, Activator X places it in areas where calcium is most needed, such as bones and teeth. It has been reported to reverse damage done by calcification which results in diseases such as atherosclerosis and osteoporosis. It also helps reverse tooth decay. It is suggested that Activator X supplements are be taken with Vitamin A and D3.
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8. Boron/Borax
Another good supplement that can be used to remove fluoride from the human body is the mineral Boron. It is naturally present in beets, which can be eaten raw, steamed, cooked as well as in a powder supplement. It is also present in other foods, such as dried plums. Borax is an inexpensive source of boron that can be bought in most grocery stores.
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What Else Can Help Boost Your Pineal Gland Function?
In addition to the supplements listed above, there are many foods that help decalcify and improve the function of the pineal gland, while detoxifying other parts of the body. These include: cilantro, tamarind, Goji berries, watermelon, bananas, honey, coconut oil, hemp seeds, seaweed, Noni Juice, garlic, Chaga mushroom, raw lemon juice. Pineal gland decalcification can also be gained by eating more alkaline foods. See a list of such foods here: Alkaline Foods to Help Decalcify the Pineal Gland.
About the Author
Anna Hunt is a staff writer for WakingTimes.com and an entrepreneur with over a decade of experience in research and editorial writing. She and her husband run a preparedness e-store outlet at www.offgridoutpost.com, offering GMO-free storable food and emergency kits. Anna is also a certified Hatha yoga instructor at Atenas Yoga. She enjoys raising her children and being a voice for optimal human health and wellness. Read more of her excellent articles here.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of Waking Times or its staff.
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Grand-paternal age and the development of autism-like symptoms in mice progeny.

Transl Psychiatry. 2014 Apr 29;4:e386. doi: 10.1038/tp.2014.27.
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Abstract
Advanced paternal age (APA) contributes to the risk of autism spectrum disorders (ASDs) in children. In this study, we used a mouse model to investigate the effects of APA on behavioral features related to autistic syndromes (that is, social deficits, communication impairments and stereotypic/repetitive behaviors). We also examined whether such effects are transmitted across generations. To do this, males aged 15 months (APA) and 4 months (control) were bred with 4-month-old females, and the resulting offspring (F1) and their progeny (F2; conceived by 4-month-old parents) were tested for the presence and severity of ASD-like behaviors. Our results indicate that APA resulted in offspring that displayed distinctive symptoms of ASD. We found that both F1 conceived from old fathers and F2 derived from old grandfathers displayed increased ultrasound vocalization (USV) activity, decreased sociability, increased grooming activity and increased anxiety-like responses. Moreover, such abnormalities were partially transmitted to the second generation of mice, having APA grandfathers. In conclusion, our study suggests that the risk of ASD could develop over generations, consistent with heritable mutations and/or epigenetic alterations associated with APA.
PMID: 24780920 [PubMed - as supplied by publisher]