Association of Paternal Age and Risk for Major Congenital Anomalies From the National Birth Defects Prevention Study, 1997 to 2004

Titre du document / Document title
Association of Paternal Age and Risk for Major Congenital Anomalies From the National Birth Defects Prevention Study, 1997 to 2004
Auteur(s) / Author(s)
GREEN Ridgely Fisk ; DEVINE Owen ; CRIDER Krista S. ; OLNEY Richard S. ; ARCHER Natalie ; OLSHAN Andrew F. ; SHAPIRA Stuart K. ;
Résumé / Abstract
PURPOSE: The objective of this study was to examine the associations between paternal age and birth defects of unknown etiologies while carefully controlling for maternal age. METHODS: By using 1997 to 2004 data from the National Birth Defects Prevention Study, we fit logistic regression models with paternal and maternal age as continuous variables while adjusting for demographic and other factors. RESULTS: Elevated odds ratios (ORs) for each year increase in paternal age were found for cleft palate (OR. 1.02, 95% confidence interval [95% CI], 1.00-1.04), diaphragmatic hernia (OR, 1.04; 95% CI, 1.02- 1.06), right ventricular outflow tract obstruction (OR, 1.03; 95% CI, 1.01-1.04), and pulmonary valve stenosis (OR, 1.02, 95% CI, 1.01-1.04). At younger paternal ages, each year increase in paternal age correlated with increased odds of having offspring with encephalocele, cataract, esophageal atresia, anomalous pulmonary venous return, and coarctation of the aorta, but these increased odds were not observed at older paternal ages. The effect of paternal age was modified by maternal age for gastroschisis, omphalocele, spina bifida, all orofacial clefts, and septal heart defects. CONCLUSIONS: Our findings suggest that paternal age may be a risk factor for some multifactorial birth defects.
Revue / Journal Title
Annals of epidemiology ISSN 1047-2797 CODEN ANNPE3
Source / Source
2010, vol. 20, no3, pp. 241-249 [9 page(s) (article)]
Langue / Language
Anglais

Editeur / Publisher
Elsevier, New York, NY, ETATS-UNIS (1990) (Revue)

Mots-clés d'auteur / Author Keywords
Congenital Abnormalities ; Maternal Age ; Paternal Age ; Risk Factors ;
Localisation / Location
INIST-CNRS, Cote INIST : 22935, 35400018960899.0090


Nº notice refdoc (ud4) : 22441477

and advanced paternal age at delivery (greater than 30 year-old).

J Autism Dev Disord. 2010 Apr 1. [Epub ahead of print]

Prenatal and Perinatal Risk Factors for Autism in China.
Zhang X, Lv CC, Tian J, Miao RJ, Xi W, Hertz-Picciotto I, Qi L.

School of Public Health, Tianjin Medical University, Tianjin, 300070, China.

We conducted a case-control study using 190 Han children with and without autism to investigate prenatal and perinatal risk factors for autism in China. Cases were recruited through public special education schools and controls from regular public schools in the same region (Tianjin), with frequency matching on sex and birth year. Unadjusted analyses identified seven prenatal and seven perinatal risk factors significantly associated with autism. In the adjusted analysis, nine risk factors showed significant association with autism: maternal second-hand smoke exposure, maternal chronic or acute medical conditions unrelated to pregnancy, maternal unhappy emotional state, gestational complications, edema, abnormal gestational age (<35 or >42 weeks), nuchal cord, gravidity >1, and advanced paternal age at delivery (>30 year-old).

PMID: 20358271 [PubMed - as supplied by publisher]