Wednesday, June 27, 2012

Advanced paternal age is associated with altered DNA methylation at brain-expressed imprinted loci in inbred mice: implications for neuropsychiatric disease.


Advanced paternal age is associated with altered DNA methylation at brain-expressed imprinted loci in inbred mice: implications for neuropsychiatric disease.Smith RG, Reichenberg A, Kember RL, Buxbaum JD, Schalkwyk LC, Fernandes C, Mill J. Source Institute of Psychiatry, King's College London, London, UK.

Wednesday, June 20, 2012

Paternal Age and Risk for Cesarean Delivery. Faro R, Santolaya-Forgas J, Canterino JC, Oyelese Y, Ananth CV. Source Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ. Abstract Abstract Objective: To determine whether advanced paternal age is associated with increased risk for cesarean delivery. Study Design: We used the 1990-2002 US linked live birth and infant death data files restricted to primiparous Caucasian and African-American women that delivered a singleton birth at ≥20 week's gestation (12.5 million). We examined temporal trends and risk ratios of cesarean birth in relation to paternal age before and after adjustments for known confounders. Results: Among Caucasians, the cesarean delivery rates were 21.1%, 26.7% and 31.8% in fathers aged 20-29, 30-39 and ≥40 years, respectively.Among African-Americans, the corresponding rates were 24.1%, 33.2%, and 38.1%, respectively.These increased cesarean delivery rates persisted in analyses stratified by maternal age before and after adjustment for a variety of confounders. Conclusions: These findings suggest that increasing paternal age may be associated with an increased risk for cesarean delivery in primiparous women.


    2012 Jun 18. [Epub ahead of print]

    Paternal Age and Risk for Cesarean Delivery.

    Source

    Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ.

    Abstract

    Abstract Objective: To determine whether advanced paternal age is associated with increased risk for cesarean delivery. Study Design: We used the 1990-2002 US linked live birth and infant death data files restricted to primiparous Caucasian and African-American women that delivered a singleton birth at ≥20 week's gestation (12.5 million). We examined temporal trends and risk ratios of cesarean birth in relation to paternal age before and after adjustments for known confounders. Results: Among Caucasians, the cesarean delivery rates were 21.1%, 26.7% and 31.8% in fathers aged 20-29, 30-39 and ≥40 years, respectively.Among African-Americans, the corresponding rates were 24.1%, 33.2%, and 38.1%, respectively.These increased cesarean delivery rates persisted in analyses stratified by maternal age before and after adjustment for a variety of confounders. Conclusions: These findings suggest that increasing paternal age may be associated with an increased risk for cesarean delivery in primiparous women.