[The value of paternal age on the outcome of intrauterine insemination].

Ginecol Obstet Mex. 2013 Jun;81(6):329-33.

[The value of paternal age on the outcome of intrauterine insemination].

[Article in Spanish]

Carballo E, Roque A, Durán-Monterrosas LA, Kably Ambe A.

Source

Centro Especializado para la Atención de la Mujer, CEPAM, Hospital Angeles Lomas, Estado de México. draecm@gmail.com

Abstract

BACKGROUND:

Although age to conceive has been delayed in both males and females, male age is controversial as decisive for this purpose.

OBJECTIVE:

To describe the results of intrauterine insemination pregnancy according to the age of the man. To determine whether this variable modifies semen parameters. To analyze whether pregnancy outcomes are modified by sperm morphology.

PATIENTS AND METHODS:

A descriptive, retrospective, longitudinal and analytical study. We analyzed 2,276 intrauterine insemination cycles performed in the Mexican Center for Fertility CEPAM from January 2000 to December 2012. We included only women under 35 years old without tubal occlusion. Semen parameters were evaluated after capacitation and the pregnancy rate by male age group and sperm morphology was analyzed. The results were analyzed with SPSS 20. Continuous variables were reported as means and their standard deviations and logistic regression univariate to determine the statistical significance. The categorical variables were evaluated in frequencies and percentages.

RESULTS:

2,276 intrauterine insemination cycles were pooled according to the age of the male. The lower pregnancy rate was found in the group of men over 50 years. There was negative correlation between the increasing age with the total motile cell volume and morphology. There was only one pregnancy from a male over 50 years. When morphology was less than 4%, the pregnancy rate was significantly lower after 45 years; if it was more than 4% this effect was not observed.

CONCLUSION:

Male age affects pregnancy outcomes in intrauterine insemination cycles, as long as the sperm morphology is altered.

Nat Rev Endocrinol. 2013 Jul 9. doi: 10.1038/nrendo.2013.141. [Epub ahead of print] Growth and development: Paternal age and offspring outcomes. [No authors listed] PMID: 23835369 [PubMed - as supplied by publisher]

Nat Rev Endocrinol. 2013 Jul 9. doi: 10.1038/nrendo.2013.141. [Epub ahead of print]

Growth and development: Paternal age and offspring outcomes.

[No authors listed]

PMID: 23835369 [PubMed - as supplied by publisher]Nat Rev Endocrinol. 2013 Jul 9. doi: 10.1038/nrendo.2013.141. [Epub ahead of print] Growth and development: Paternal age and offspring outcomes. [No authors listed] PMID: 23835369 [PubMed - as supplied by publisher]

Fertil Steril. 2013 Jul 3. pii: S0015-0282(13)00724-3. doi: 10.1016/j.fertnstert.2013.06.024. [Epub ahead of print] Paternal age and sperm methylation status. De Jonge CJ. Source Department of Obstetrics, Gynecology, and Women's Health, University of Minnesota, Minneapolis, Minnesota. PMID: 23830107 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/23830107

Fertil Steril. 2013 Jul 3. pii: S0015-0282(13)00724-3. doi: 10.1016/j.fertnstert.2013.06.024. [Epub ahead of print]

Paternal age and sperm methylation status.

De Jonge CJ.

Source

Department of Obstetrics, Gynecology, and Women's Health, University of Minnesota, Minneapolis, Minnesota.

PMID: 23830107 [PubMed - as supplied by publisher]

Characteristics of first-time fathers of advanced age: a Norwegian population-based study.

BMC Pregnancy Childbirth. 2013 Jan 30;13:29. doi: 10.1186/1471-2393-13-29.

Characteristics of first-time fathers of advanced age: a Norwegian population-based study.

Nilsen AB, Waldenström U, Rasmussen S, Hjelmstedt A, Schytt E.

Source

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden. abvn@hib.no

Abstract

BACKGROUND:

The modern phenomenon of delayed parenthood applies not only to women but also to men, but less is known about what characterises men who are expecting their first child at an advanced age. This study investigates the sociodemographic characteristics, health behaviour, health problems, social relationships and timing of pregnancy in older first-time fathers.

METHODS:

A cross-sectional study was conducted of 14 832 men who were expecting their first child, based on data from the Norwegian Mother and Child Cohort Study (MoBa) carried out by the Norwegian Institute of Public Health. Data were collected in 2005-2008 by means of a questionnaire in gestational week 17-18 of their partner's pregnancy, and from the Norwegian Medical Birth Register. The distribution of background variables was investigated across the age span of 25 years and above. Men of advanced age (35-39 years) and very advanced age (40 years or more) were compared with men aged 25-34 years by means of bivariate and multivariate logistic regression analyses.

RESULTS:

The following factors were found to be associated with having the first child at an advanced or very advanced age: being unmarried or non-cohabitant, negative health behaviour (overweight, obesity, smoking, frequent alcohol intake), physical and mental health problems (lower back pain, cardiovascular diseases, high blood pressure, sleeping problems, previous depressive symptoms), few social contacts and dissatisfaction with partner relationship. There were mixed associations for socioeconomic status: several proxy measures of high socioeconomic status (e.g. income >65,000 €, self-employment) were associated with having the first child at an advanced or very advanced age, as were several other proxy measures of low socioeconomic status (e.g. unemployment, low level of education, immigrant background).The odds of the child being conceived after in vitro fertilisation were threefold in men aged 34-39 and fourfold from 40 years and above.

CONCLUSIONS:

Men who expect their first baby at an advanced or very advanced age constitute a socioeconomically heterogeneous group with more health problems and more risky health behaviour than younger men. Since older men often have their first child with a woman of advanced age, in whom similar characteristics have been reported, their combined risk of adverse perinatal outcomes needs further attention by clinicians and researchers.