Growing evidence shows that the health of offspring of older fathers is at risk. Paternal age of 35 is advanced.Paternal age is the major source of de novo genetic disorders. The rise in offspring with "autism" is expected as paternal age rises. Alzheimer's, schizophrenia,autoimmune disorders are increasing.
Mutations with a deleterious effect that is expressed after the average reproductive period are not effectively selected against and can accumulate in the germline.
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