Growing evidence shows that the health of offspring of older fathers is at risk. Paternal age of 35 is advanced.Paternal age is the major source of de novo genetic disorders. The rise in offspring with "autism" is expected as paternal age rises. Alzheimer's, schizophrenia,autoimmune disorders are increasing.
Tuesday, April 01, 2008
Will They Find What the Paternal Age Effect Looks Like Genetically in Schizophrenia
Dr. Sebat is currently applying the mutation-screening method in studies involving a greater number of patients and in other illnesses. Among other things, he seeks to determine whether spontaneous mutations play as significant a role in schizophrenia as they do in autism, as revealed by a study he co-authored a year ago with CSHL Professor Michael Wigler.
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