Growing evidence shows that the health of offspring of older fathers is at risk. Paternal age of 35 is advanced.Paternal age is the major source of de novo genetic disorders. The rise in offspring with "autism" is expected as paternal age rises. Alzheimer's, schizophrenia,autoimmune disorders are increasing.
Friday, August 24, 2012
Rate of de novo mutations and the importance of father's age to disease risk.
Rate of de novo mutations and the importance of father's age to disease risk.
Kong A, Frigge ML, Masson G, Besenbacher S, Sulem P, Magnusson G, Gudjonsson SA, Sigurdsson A, Jonasdottir A, Jonasdottir A, Wong WS, Sigurdsson G, Walters GB, Steinberg S, Helgason H, Thorleifsson G, Gudbjartsson DF, Helgason A, Magnusson OT, Thorsteinsdottir U, Stefansson K.
Nature. 2012 Aug 22;488(7412):471-5. doi: 10.1038/nature11396.
PMID: 22914163 [PubMed - in process]
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