Saturday, January 13, 2007

Paternal Age Effect and Disorders Known in 1999

Table II. Long-term effects of paternal ageing on offspring from table on page 2373 of Long –term effects of delayed parenthood by J.J. Tarin, J. Brines, and A. Cano

Dominant disorders
Wilms tumour, thanatophoric dysplasia, retinitis pigmentosa, osteogenisis imperfecta type IIA, acrodysostosis, achondroplasia, Apert’s disease, fibrodysplasia ossificans progressiva, aniridia, bilateral retinoblastoma, multiple exostoses, Marfan’s, Lesch-Nyan’s, Pfeiffer’s, Wardenburg’s, Treacher-Collins, Soto’s, and Crouzon’s syndromes, basel cell nevus, cleidocranial dysostosis, polyposis coli, oculodentodigital syndrome, Costello syndrome , progeria, Recklinghausen’s neurofibromatosis, tuberous sclerosis and renal polycystic kidney disease.

X-linked recessive diseases
Haemophilia A and Duchenne’s muscular dystrophy

Non-cytogenetic congential defects
Congential cataracts, reduction defects of the upper limb, nasal aplasia, pulmonic and urethtal stenosis, perauricular cyst, cleft palate,1 neural tube defects

Athetoid /dystonic cerebral palsy and congenital hemiplegia

Psychotic disorders

Decreased learning capacity and/or mental retardation



At 1:31 AM , Anonymous Anonymous said...

how can an x-linked disease be related to the age of the father????

At 3:09 AM , Anonymous Anonymous said...

Since sperm can carry these mutations, perhaps these could produce a spontaneous female carrier of an x-linked disorder?

At 8:22 AM , Blogger concerned heart said...

Yes, definetly, the mother who has had an older father can carry the X-chromosome damage to some of her offspring. That is why with so many men fathering later there have been warnngs of double recessive conditons expanding and certainly more boys with hemophilia and Duchennes etc. Maybe some autism can be explained this way.


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