FREQUENCY OF NUMERICAL AND STRUCTURAL ABERRATIONS WAS SIGNIFICANTLY GREATER IN CHROMOSOMES OF OLDER DONORS (59-74) VS (23-39)

Fertility and Sterility
Volume 76, Issue 6, 2001, Pages 1119-1123


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Effect of paternal age on human sperm chromosomes

Sartorelli, E.M.P.a , Mazzucatto, L.F.b , De Pina-Neto, J.M.b

a Departamento de Biologia Celular, Embriologia e Genética, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil
b Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, São Paulo, Brazil


Abstract

Objective: To investigate whether increased age alters the frequency and type of chromosomal anomalies in human spermatozoa. Design: Semen specimens were collected from donors via masturbation; cytogenetic studies were performed on sperm chromosomes after heterologous (human-hamster) in vitro fertilization. Setting: Cytogenetics Laboratory, Genetics Department, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil. Patients(s): Seven men ages 59-74 (older group) and five men ages 23-39 (control group). Main Outcome Measure(s): Frequency and types of chromosomal anomalies in older and control group donors. Result(s): The frequency of numerical and structural aberrations (acentric fragments and complex radial figures) was significantly greater in chromosomes of older donors when compared with those of the control group. Conclusion(s): The higher frequency of sperm chromosome aberrations in older men was mainly a result of increased nondisjunction, acentric fragments, and complex radial figures. © 2001 by American Society for Reproductive Medicine.

Author Keywords

Chromosomal aberrations; Cytogenetics; Human spermatozoa