delayed fatherhood long-term effects offspring

Delayed fatherhood in mice decreases reproductive fitness
and longevity of offspring1
Short title: Long-term effects of paternal age on offspring
Summary sentence: Delayed fatherhood decreases reproductive fitness and longevity of
offspring in the mouse model
Key words: delayed fatherhood long-term effects offspring
Silvia García-Palomares3, Samuel Navarro4, José F. Pertusa3, Carlos Hermenegildo5,6,
Miguel A. García-Pérez5,7, Francisco Rausell3, Antonio Cano8 and Juan J. Tarín2,3
1Supported by grant BFI2003-04761 from “Ministerio de Ciencia y Tecnología”, cofinanced by
the “Fondo Europeo de Desarrollo Regional (FEDER); grant ISCIII2006-PI0405 from “Instituto
de Salud Carlos III, Fondo de Investigación Sanitaria, Ministerio de Sanidad y Consumo”,
cofinanced by the FEDER; and grants GV2004-B-206 and AE/2007/001 from “Generalitat
Valenciana, Conselleria d’Émpresa, Universitat i Ciencia”.
2Correspondence: Juan J. Tarín, Department of Functional Biology and Physical Anthropology,
Faculty of Biological Sciences, University of Valencia, Dr. Moliner 50, 46100 Burjassot,
Valencia, Spain; Tel. 34-96-354 3221; E-mail: tarinjj@uv.es
3Department of Functional Biology and Physical Anthropology, Faculty of Biological Sciences,
University of Valencia, Burjassot, 46100 Valencia, Spain
4Department of Pathology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain
5Research Unit, Hospital Clínico de Valencia, 46010 Valencia, Spain