Monday, January 19, 2009

Aberrant epigenetic regulation could explain the relationship of paternal age to schizophrenia

1: Schizophr Bull. 2007 Nov;33(6):1270-3. Epub 2007 Aug 21. Links
Aberrant epigenetic regulation could explain the relationship of paternal age to schizophrenia.

Perrin MC, Brown AS, Malaspina D.
Department of Psychiatry, School of Medicine, New York University, New York, NY, USA.

The causal mechanism underlying the well-established relation between advancing paternal age and schizophrenia is hypothesized to involve mutational errors during spermatogenesis that occur with increasing frequency as males age. Point mutations are well known to increase with advancing paternal age while other errors such as altered copy number in repeat DNA and chromosome breakage have in some cases also been associated with advancing paternal age. Dysregulation of epigenetic processes may also be an important mechanism underlying the association between paternal age and schizophrenia. Evidence suggests that advancing age as well as environmental exposures alter epigenetic regulation. Errors in epigenetic processes, such as parental imprinting can have serious effects on the offspring both pre- and postnatally and into adulthood. This article will discuss parental imprinting on the autosomal and X chromosomes and the alterations in epigenetic regulation that may lead to such errors.

PMID: 17712030 [PubMed - indexed for MEDLINE]

Related ArticlesPaternal age and intelligence: implications for age-related genomic changes in male germ cells. [Psychiatr Genet. 2005] ReviewPaternal factors and schizophrenia risk: de novo mutations and imprinting. [Schizophr Bull. 2001] ReviewGrowth and schizophrenia: aetiology, epidemiology and epigenetics. [Novartis Found Symp. 2008] ReviewEpigenetic regulation of gene expression in the inflammatory response and relevance to common diseases. [J Periodontol. 2008] Paternal age and sporadic schizophrenia: evidence for de novo mutations. [Am J Med Genet. 2002] » See Reviews... | » See All...



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