Advanced paternal age is associated with altered DNA methylation at brain-expressed imprinted loci in inbred mice: implications for neuropsychiatric disease.
Growing evidence shows that the health of offspring of older fathers is at risk. Paternal age of 35 is advanced.Paternal age is the major source of de novo genetic disorders. The rise in offspring with "autism" is expected as paternal age rises. Alzheimer's, schizophrenia,autoimmune disorders are increasing.