"CERTAIN FRAGILE SITES MAY POSSIBLY PREDISPOSE TO CHROMOSOME BREAKAGE AND REARRANGEMENTS IN MEOSIS"

Clinical Genetics
Volume 26, Issue 3, 1984, Pages 174-177



This article has been cited 9 times in Scopus:
(Showing the 2 most recent)
Karadeniz, N.N. , Tunca, Y. , ImirzaliogÌŒlu, N.
New heritable fragile site at 15q13 in both members of a nonconsanguineous couple
(2003) American Journal of Medical Genetics


Denison, S.R. , Simper, R.K. , Greenbaum, I.F.
How common are common fragile sites in humans: Interindividual variation in the distribution of aphidicolin-induced fragile sites
(2003) Cytogenetic and Genome Research


View details of all 9 citations





Fragile sites and chromosome breakpoints in constitutional rearrangements II. Spontaneous abortions, stillbirths and newborns

Hecht, F., Hecht, B.K.

Genetics Center of Southwest Biomedical Research Institute, Tempe, AZ 85281, United States


Abstract

Certain fragile sites may possibly predispose to chromosome breakage and rearrangements in meiosis. To test this hypothesis, we examined 894 breakpoints found in spontaneous abortions, stillbirths and live births of which 165 (18.5%) were in bands with fragile sites. Compared to an expectation of 98 (11%), there was a significant excess of breakpoints in fragile site bands (P<0.001). Together with data from amniocenteses, there is now evidence suggesting that certain fragile sites may be prone to fragility in meiosis.